Lonely but diverse
نویسنده
چکیده
NEWS NEWS What do cerebellar Purkinje cells, working myocardium, skeletal muscle myocytes and cochlear inner hair cells (IHCs) have in com-mon? Their high-voltage activated (HVA) Ca 2+ currents are mediated almost exclusively by a single calcium channel type: Cav2.1 (P-type) in Purkinje cells, Cav1.2 L-type in the heart, Cav1.1 in skeletal muscle and Cav1.3 in IHCs. In most other electrically excitable cells several HVA Ca 2+-channel types coexist. There, individual Ca 2+-channels can only be studied in the presence of complex cocktails of drugs and toxins sparing the channel component of interest.
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2013